safety test

SAFETY TESTS

The following safety tests were performed on the raw material ” Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40 ”.

  • Cell toxicity (in-House Lab.)
  • Bacterial Reverse Mutation Assay test (GLP Lab.)
  • Chromosomal test (GLP Lab.)

The following additional tests are conducted on the safety of ‘Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40’ and animal testing of this ingredient is never carried out.

  • Skin Irritation using EPISKIN
  • Eye Irritation using EpiOcular test
  • Skin Sensitization : Local Lymph node Assay : BrdU-ELISA)
  • in vitro 3T3 NRU Photoxity Test

CLINICAL TESTS

Single Human Patch Test
Bolca Anti-Wrinkle Facial Serum
(I.E.C. Korea @ Chonnam National Univ. Hospital)

Clinical Test (I.E.C. Korea)
Bolca Anti-Wrinkle Facial Serum
(I.E.C. Korea)

After 4 weeks test shows improvement of roughness, elasticity, nasolabial line from 70% of applicant. Different from individuals but the efficacy can be seen normally within 2 weeks

Effectivenss
Ratio
Roughness
16/22
72%
Net Elasticity
22/22
100%
Nasolabial line
15/22
68%